Asthma guidelines: Why aminophylline?

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Asthma guidelines: why aminophylline?

274 May 2013, Vol. 103, No. 5 SAMJ Asthma guidelines: Why aminophylline? To the Editor: While it is always encouarging to see new clinical guidelines to help direct therapy for important clinical conditions, the ‘Guidelines for the management of acute asthma in adults’ are disappointing in two regards. Firstly, a majority of acute asthma attacks in adults are managed in the emergency centre and...

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Salbutamol or aminophylline for acute severe asthma: how to choose which one, when and why?

Acute, severe exacerbations of asthma present a challenge due to the significant morbidity associated with this presentation. For exacerbations that are refractory to initial treatments with inhaled and oral therapies, there is still doubt about which intravenous therapies are most likely to be helpful. β-2 agonists and aminophylline have differing mechanisms of action that also affect their ad...

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Interaction between isoprenaline and aminophylline in asthma.

Campbell, I. A., Middleton, W. G., McHardy, G. J. R., Shotter, Margaret V., McKenzie, R., and Kay, A. B. (1977). Thorax, 32, 424-428. Interaction between isoprenaline and aminophylline in asthma. Using a factorially designed study, 38 patients with bronchial asthma received a single dose of either isoprenaline by inhalation (9), aminophylline intravenously (10), isoprenaline and aminophylline (...

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Intravenous salbutamol and aminophylline in asthma: a search for synergy.

The bronchodilation produced by increasing intravenous doses of aminophylline, salbutamol, and a combination of aminophylline and salbutamol given in random order was determined in 10 stable asthmatics on three consecutive days. On a fourth day, response to placebo injections was determined. Forced expiratory volume in one second (FEV1) was measured at two-minute intervals after each dose until...

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Randomised controlled trial of aminophylline for severe acute asthma.

OBJECTIVES To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. STUDY DESIGN Randomised, double blind, placebo controlled trial of 163 children admitted to hospital with asthma who were unresponsive to nebulise...

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ژورنال

عنوان ژورنال: South African Medical Journal

سال: 2013

ISSN: 2078-5135

DOI: 10.7196/samj.6929